The comparison effects of propranolol, caffeine and diazepam on lidocaine-induced convulsions in mice

The purpose of this study was to evaluate the study the comparison effect of propranolol, caffeine and diazepam on lidocaine-induced convulsions in mice. The study was done in 4 groups (5 mice in each group). Lidocaine was administrated at dose 30 mg/kg intraperitoneally (IP) in group 1. Diazepam was injected at dose 2 mg/kg-IP 15 min before lidocaine in group 2. Propranolol was injected at dose 5 mg/kg-IP 15 min before lidocaine in group 3. Caffeine was injected at dose 10 mg/kg-IP 15 min before lidocaine in group 4. The latency to first convulsion, the duration and the number of convulsions was observed for 30 min and were recorded in the mice and the mean of these factors was evaluated. In group 1 (which received only lidocaine), the mean of the latency to first convulsion, the duration and the number of convulsions were 4.6 ± 0.24 min, 21.6 ± 2.8 and 353.8 ± 0.65 S respectively. Convulsion was not seen with diazepam in group 2 (which received Lidocaine plus diazepam). In groups 3 and 4 (which received Lidocaine plus Propranolol and Caffeine) the number and duration of the convulsions were decreased and Convulsion latency of lidocaine was increased at mice. Thus, the results of this study shows the propranolol and caffeine can reduced lidocaineinduced convulsions. Keywords— Convulsion, Lidociane, Diazpam, Caffeine, Propranolol, Mice